A two-minute collapse in the second half by Ghana’s Black Stars helped Portugal pick up a 3-2 win in their Group H clash.
Andre Ayew’s 73rd-minute goal cancelled out Cristiano Ronaldo’s penalty and appeared to have given the Stars a new lease of life.
However, goals from Joao Felix and Rafael Leao put Portugal back in control.
Osman Bukari headed home a second for the Black Stars but the Portuguese held on, despite nine added minutes to pick up all three points.
The defeat would have been hard for Otto Addo’s men who stifled Portugal for much of the first half and the beginning of the second.